This paper reviews the history of modelling for cervical cancer vaccination. We provide an interpretation and summary of conclusions pertaining to the usefulness of different models, the predicted epidemiological impact of vaccination and the cost-effectiveness of adolescent, catch-up and sex-specific vaccination strategies. To date, model results predict a critical role for vaccination in reducing the burden of cervical disease, with cost-effectiveness being consistently shown across studies using a common threshold of US $50,000 per QALY, but further clinical and epidemiological data are required to confirm these findings. Through this paper, we aim to provide useful insights for decision-makers as they examine how to best evaluate the potential impact of vaccines against cervical cancer and determine how to best incorporate vaccination into practice.

译文

:本文回顾了宫颈癌疫苗接种模型的历史。我们提供了有关以下结论的解释和总结:不同模型的有效性,疫苗的流行病学预测影响以及青少年,追赶和针对特定性别的疫苗接种策略的成本效益。迄今为止,模型结果预测疫苗接种在减轻子宫颈疾病负担中的关键作用,成本效益在每项QALY 50,000美元的通用阈值的研究中始终得到证实,但需要进一步的临床和流行病学数据来证实这些发现。通过本文,我们旨在为决策者提供有用的见解,帮助他们了解如何最好地评估疫苗对宫颈癌的潜在影响,并确定如何将疫苗接种最佳地应用于实践。

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