INTRODUCTION:The role of botulinum toxin as a therapeutic agent for several conditions is expanding. We sought to determine if botulinum toxin is safe and effective in treating patients with cervical dystonia and maxillofacial conditions. Our purpose was to establish a safety and efficacy profile to determine whether or not this treatment may be used prophylactically in patients undergoing dental implant therapy. METHODS:We performed a systematic search of the literature to identify randomized clinical trials evaluating patients treated with botulinum toxin as an adjunct to dental implant therapy, maxillofacial conditions including temporomandibular disorders (TMD), and cervical dystonia. RESULTS:Four randomized controlled trials (RCTs) met our search criteria in the area of cervical dystonia and chronic facial pain. No RCTs were identified evaluating dental implant therapy. Patients with cervical dystonia exhibited significant improvements in baseline functional, pain, and global assessments compared to placebo. Adverse events were mild and transient with numbers needed to harm (NNH) ranging from 12 to 17. Patients with chronic facial pain improved significantly from baseline in terms of pain compared to placebo. Rates of adverse events were less than 1%. CONCLUSION:Botulinum toxin appears relatively safe and effective in treating cervical dystonia and chronic facial pain associated with masticatory hyperactivity. No literature exists evaluating its use in dental implantology. Randomized clinical trials are warranted to determine its safety and efficacy in dental implantology and other maxillofacial conditions such as bruxism.

译文

简介:肉毒杆菌毒素在多种情况下作为治疗剂的作用正在扩大。我们试图确定肉毒杆菌毒素在治疗患有颈肌张力障碍和颌面部疾病的患者中是否安全有效。我们的目的是建立安全性和有效性概况,以确定在接受牙种植体治疗的患者中是否可以预防性使用该治疗方法。
方法:我们进行了系统的文献检索,以鉴定评估用肉毒杆菌毒素作为牙科植入物治疗,颌面部疾病(包括颞下颌疾病(TMD)和颈肌张力障碍)的辅助治疗的患者的随机临床试验。
结果:四项随机对照试验(RCT)在宫颈肌张力障碍和慢性面部疼痛方面符合我们的搜索标准。未鉴定出评估牙种植体治疗的RCT。与安慰剂相比,宫颈肌张力障碍患者在基线功能,疼痛和整体评估方面表现出显着改善。不良事件是轻度和短暂的,需要伤害的数字(NNH)在12到17之间。与安慰剂相比,慢性面部疼痛患者在疼痛方面较基线有了显着改善。不良事件的发生率小于1%。
结论:肉毒杆菌毒素在治疗颈肌张力障碍和咀嚼亢进引起的慢性面部疼痛方面似乎相对安全有效。没有文献评估其在牙种植学中的用途。必须进行随机临床试验来确定其在牙种植术和其他颌面疾病(例如磨牙症)中的安全性和有效性。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录