Fatigue is a common symptom of patients with chronic kidney disease, but seldom investigated after transplantation. We determined the prevalence, impact and related factors of severe fatigue in kidney transplant recipients (KTRs). Medical records and questionnaires were used to assess kidney function, donor characteristics, fatigue (Checklist Individual Strength), functional impairments (Sickness Impact Profile), work status, body mass index (BMI), pain, depressive symptoms, social support and sleeping problems in 180 participating KTRs. KTRs were compared with sex- and age-matched population-based controls. KTRs were significantly more often severely fatigued (39%) compared to matched controls (22%; P = 0.001). Severely fatigued KTRs had significantly more functional impairments than nonseverely fatigued recipients (effect size ≥ 0.7) P < 0.001, and less often a paid job (27% vs. 48%, P = 0.005). Univariate analysis showed that severely fatigued KTRs received more often a kidney from a deceased donor, had a higher BMI, more pain, discrepancy in social support, depressive symptoms and sleeping problems. In a multivariate analysis (n = 151) the latter two associations remained significant. Severe fatigue is a highly prevalent and disabling symptom in KTRs. Moreover, severe fatigue after kidney transplantation is more strongly related to behavioural and psychosocial factors than specific transplantation-related factors. Findings have implications for fatigue management.

译文

:疲劳是慢性肾脏疾病患者的常见症状,但很少在移植后进行检查。我们确定了肾移植受者(KTR)中严重疲劳的患病率,影响和相关因素。病历和问卷用于评估肾功能,供体特征,疲劳(清单个人力量),功能障碍(疾病影响概况),工作状态,体重指数(BMI),疼痛,抑郁症状,社会支持和睡眠问题。 180个参与的KTR。将KTR与性别和年龄相匹配的基于人群的对照进行了比较。与匹配的对照组(22%; P = 0.001)相比,KTR严重疲劳(39%)的频率明显更高。严重疲劳的KTR比非严重疲劳的接受者具有更大的功能障碍(效应量≥0.7)P <0.001,而有酬工作的频率更低(27%比48%,P = 0.005)。单因素分析表明,严重疲劳的KTR经常从死者的肾脏获得肾脏,BMI更高,疼痛更多,社会支持差异,抑郁症状和睡眠问题。在多变量分析(n = 151)中,后两个关联仍然显着。严重疲劳是KTR的高度普遍和致残的症状。此外,与特定的移植相关因素相比,肾移植后的严重疲劳与行为和社会心理因素的相关性更高。研究结果对疲劳管理有影响。

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