This report describes a case of diabetes insipidus associated with acute myelogenous leukemia. An 11-year-old boy presented with fatigue, polydipsia and polyuria. His evaluation revealed a diagnosis of acute myelogenous leukemia FAB-M2, and a water deprivation test confirmed the diagnosis of central diabetes insipidus. His brain magnetic resonance imaging (MRI) showed a thickened, enhancing pituitary stalk with absence of the normal hyperintense signal in the posterior pituitary. He was treated with systemic chemotherapy, intensive intrathecal therapy, and 1,000 cGy to the pituitary. The patient achieved a remission but continued to need desmopressin therapy to control his diabetes insipidus. Diabetes insipidus is a rare complication of acute myelogenous leukemia that can be caused by leukemic infiltration of the pituitary. The diabetes insipidus is irreversible despite intensive systemic and central nervous system chemotherapy and radiation.

译文

:本报告描述了与尿崩症相关的一例尿崩症。一个11岁的男孩表现出疲劳,多饮和多尿。他的评估显示出诊断为急性粒细胞性白血病FAB-M2,而缺水测试证实了对中枢性尿崩症的诊断。他的脑磁共振成像(MRI)显示脑垂体增厚,垂体后叶增强,而垂体后叶没有正常的高信号。他接受了全身化学疗法,强化鞘内治疗和垂体1000 cGy的治疗。该患者已缓解,但继续需要去氨加压素治疗以控制其尿崩症。尿崩症是急性髓性白血病的罕见并发症,可能由垂体的白血病浸润引起。尽管进行了强烈的全身和中枢神经系统化学疗法和放射治疗,尿崩症还是不可逆的。

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