BACKGROUND AND PURPOSE:After the introduction of the so-called "atypical antipsychotics" in the clinical experience hyperglycemia as well as increased triglyceride and cholesterol serum levels were reported in patients treated with some of these agents. In this article, the recently published population-based studies are reviewed. RESULTS:According to the available data, the risk to develop type 2 diabetes mellitus or hyperlipidemia in patients treated with clozapine and olanzapine is increased. The underlying pathomechanism still remains widely unclear. Since overweight is a known risk factor for type 2 diabetes mellitus, the weight-inducing effect of atypical antipsychotics may play an important role. CONCLUSION:Since metabolic disorders often lead to severe diseases, these side effects of antipsychotics should be paid more attention.

译文

背景与目的:在临床经验中引入所谓的“非典型抗精神病药”后,据报道,使用这些药物中的某些药物治疗的患者出现了高血糖症以及甘油三酸酯和胆固醇血清水平升高。在本文中,对最近发表的基于人群的研究进行了综述。
结果:根据现有数据,使用氯氮平和奥氮平治疗的患者发生2型糖尿病或高脂血症的风险增加。潜在的致病机理仍不清楚。由于超重是2型糖尿病的已知危险因素,因此非典型抗精神病药的体重诱导作用可能起重要作用。
结论:由于代谢紊乱常导致严重的疾病,抗精神病药物的这些副作用应引起更多重视。

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