Objective: To investigate whether serum bisphenol A (BPA) concentration is related to the occurrence of dyslipidemia. Methods: A total of 574 adults were enrolled at baseline and followed up for 5 years. Concentrations of serum BPA, triglycerides (TGs), low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol were measured. Dyslipidemia was defined as the existence of one or more of the following conditions: high-LDL-cholesterolemia (LDL ≥140 mg/dL), hypertriglyceridemia (TGs ≥150 mg/dL), or low-HDL-cholesterolemia (HDL <40 mg/dL). Participants were stratified into tertiles according to low, median, and high baseline serum BPA levels. Multivariable linear and logistic regression models were used. Data from baseline and follow-up were used for cross-sectional and longitudinal analyses, respectively. Results: In the cross-sectional analysis, compared to subjects in the low BPA tertile, those in the high BPA tertile showed a higher level of LDL cholesterol (108.1 ± 24.4 mg/dL versus 119.5 ± 26.9 mg/dL; P<.05) and a lower level of HDL cholesterol (46.2 ± 11.7 mg/dL versus 39.5 ± 7.5 mg/dL; P<.05). In multivariable linear regression models, Z-transformed BPA was positively associated with LDL cholesterol (β= 0.13, P = .002) and negatively associated with HDL cholesterol (β= -0.28; P<.001). After cross-sectionally adjusting for confounders, subjects in higher BPA exposure was associated with a higher prevalence of low-HDL-cholesterolemia. Longitudinally, in subjects without low-HDL-cholesterolemia at baseline, each SD increment in baseline BPA was associated with a higher incidence of low-HDL-cholesterolemia after adjustment for confounders (odds ratio [95% confidence interval; CI] 2.76, 95% CI 1.21, 6.29). Conclusion: Cross-sectionally, higher BPA exposure is associated with a higher prevalence of low-HDL-cholesterolemia. Longitudinally, baseline BPA is an independent predictor of the 5-year incidence of low-HDL-cholesterolemia. Abbreviations: BMI = body mass index; BPA = bisphenol A; CI = confidence interval; CVD = cardiovascular disease; EIMDS = environment, inflammation and metabolic diseases study; HDL = high density lipoprotein; LDL = low density lipoprotein; OR = odds ratio; PPAR = peroxisome proliferator-activated receptor; SBP = systolic blood pressure; TG = triglyceride; Z-BPA = Z-transformed bisphenol A.

译文


客观的:
调查血清双酚A(BPA)浓度是否与血脂异常的发生有关。
方法:
基线时共有574名成年人入组,并随访5年。测量血清BPA,甘油三酸酯(TGs),低密度脂蛋白(LDL)胆固醇和高密度脂蛋白(HDL)胆固醇的浓度。血脂异常被定义为存在以下一种或多种状况:高LDL胆固醇血症(LDL≥140mg / dL),高甘油三酯血症(TGs≥150mg / dL)或低HDL胆固醇血症(HDL <40 mg / dL)。根据低,中和高基线血清BPA水平将参与者分为三部分。使用多变量线性和逻辑回归模型。来自基线和随访的数据分别用于横截面和纵向分析。
结果:
在横断面分析中,与低BPA三分位数的受试者相比,高BPA三分位数的受试者显示更高的LDL胆固醇水平(108.1±24.4 mg / dL与119.5±26.9 mg / dL; P <.05)和降低了HDL胆固醇水平(46.2±11.7 mg / dL与39.5±7.5 mg / dL; P <.05)。在多变量线性回归模型中,Z转化的BPA与LDL胆固醇呈正相关(β= 0.13,P = .002),与HDL胆固醇呈负相关(β= -0.28; P <.001)。在针对混杂因素进行横断面调整后,BPA暴露量较高的受试者与低HDL胆固醇血症的患病率较高相关。纵向上,在基线时没有低HDL胆固醇血症的受试者中,校正混杂因素后,基线BPA的每个SD升高与低HDL胆固醇血症的发生率较高相关(比值比[95%置信区间; CI] 2.76、95% CI 1.21,6.29)。
结论:
从横截面来看,较高的BPA暴露与低HDL胆固醇血症的较高患病率相关。纵向上,基线BPA是低HDL胆固醇血症5年发生率的独立预测因子。缩写:BMI =体重指数; BPA =双酚A; CI =置信区间; CVD =心血管疾病; EIMDS =环境,炎症和代谢性疾病研究; HDL =高密度脂蛋白; LDL =低密度脂蛋白; OR =比值比; PPAR =过氧化物酶体增殖物激活受体; SBP =收缩压; TG =甘油三酸酯; Z-BPA = Z转化的双酚A。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录