Arginine supplements were given to 6 week old CBA mice beginning 3 days prior to inoculation with a murine sarcoma virus, the Moloney Sarcoma Virus (MSV). Although the basal diet contained 1.8% arginine and was therefore not arginine-deficient, supplementation of the diet and the drinking water with 0.5% arginine HCl reduced tumor incidence, lengthened the latency period, decreased tumor size, and hastened tumor regression. Arginine also increased thymic weight and cellularity in normal and in MSV-inoculated mice. The antitumor action of arginine may be related to its effect on the thymus.

译文

:在接种鼠肉瘤病毒莫洛尼肉瘤病毒(MSV)之前3天,向6周大的CBA小鼠补充精氨酸。尽管基础饮食中含有1.8%的精氨酸,因此并非精氨酸缺乏,但饮食和饮用水中添加0.5%的精氨酸HCl可以降低肿瘤的发生率,延长潜伏期,减小肿瘤的大小并加速肿瘤的消退。精氨酸还增加了正常小鼠和接种MSV的小鼠的胸腺重量和细胞数量。精氨酸的抗肿瘤作用可能与其对胸腺的作用有关。

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