R1H tumors were irradiated with a single dose of 15 Gy X rays using varying sizes of treatment fields. Damage to tumor cells and tumor stroma was determined separately by analysis of growth delay to ten times treatment volume (GD10vo) and net growth delay. GD10vo comprises irradiation effects on tumor parenchymal cells and on tumor stroma, whereas net growth delay only measures effects on tumor parenchymal cells. Stromal damage was observed to increase with increasing field size; the effect on the tumor parenchymal cells, however, was independent of the field size. An increase of GD10vo of 13 days per cm increase of field size diameter was observed. From this the velocity of neovascularization of the irradiated tumor bed was calculated to be 0.30 to 0.38 mm per day.

译文

使用不同大小的治疗区域,用15 Gy X射线单剂量照射:R1H肿瘤。通过分析至十倍治疗体积(GD10vo)的生长延迟和净生长延迟来分别确定对肿瘤细胞和肿瘤基质的损伤。 GD10vo包括对肿瘤实质细胞和肿瘤基质的辐射作用,而净生长延迟仅能测量对肿瘤实质细胞的作用。观察到间质损伤随田间大小的增加而增加。然而,对肿瘤实质细胞的影响与视野大小无关。观察到GD10vo的增加,每厘米田径直径增加13天。由此计算出被辐照的肿瘤床的新血管形成速度为每天0.30至0.38mm。

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