In addition to the priority in the discovery of the first water channel protein in the red blood cell membrane the group of Gheorghe Benga in Cluj-Napoca, Romania, also has a world priority in the discovery of the implications of water channel proteins in epilepsy and Duchenne muscular dystrophy. This priority is briefly presented here. In 1977 Benga and Morariu reported a decreased water permeability of red blood cells in children with idiopathic epilepsy (cases selected by Ileana Benga). This investigation was performed as part of a program of research of hydroelectrolytic alterations in child epilepsy. On the other hand the group of Gheorghe Benga has reported a decreased water permeability of RBC in patients with Duchenne muscular dystrophy. These findings were interpreted as an expression of generalized membrane defects affecting water permeability in epilepsy and Duchenne muscular dystrophy. In recent years this idea was confirmed by reports indicating aquaporin abnormalities in the brain of epileptic patients and in the muscle of Duchenne muscular dystrophy patients.

译文

:除了优先发现红细胞膜中的第一个水通道蛋白外,罗马尼亚克卢日-纳波卡的Gheorghe Benga小组在发现水通道蛋白在癫痫中的意义方面也具有世界优先地位和杜氏肌营养不良症。在此简要介绍此优先级。 1977年,Benga和Morariu报告了特发性癫痫患儿(Ileana Benga选择的病例)中红细胞的透水性降低。这项研究是儿童癫痫中水电解改变研究计划的一部分。另一方面,Gheorghe Benga小组报告了Duchenne肌营养不良患者的RBC透水性降低。这些发现被解释为影响癫痫和杜氏肌营养不良症中透水性的广义膜缺损的表达。近年来,有报道表明癫痫患者的大脑和杜兴氏肌营养不良患者的肌肉中存在水通道蛋白异常,这一观点得到了证实。

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