OBJECTIVES:To investigate whether DTI allows assessment of renal impairment and pathology in patients with chronic glomerulonephritis. MATERIALS AND METHODS:Seventy-five patients and 20 healthy volunteers were enrolled in this study. Renal function and kidney biopsies were evaluated. For DTI, a respiratory-triggered coronal EPI sequence was performed (TR, 1400 ms; TE, 76 ms; diffusion direction, 6; NEX, 4; b values, 0 and 600 s/mm2; slices thickness, 6 mm, with no intersection gap). Renal ADC and FA values were calculated and compared between the groups. Correlations between ADC/FA and histopathology were evaluated. RESULTS:ADC values decreased with increased stages. ADC differences in renal parenchyma at different disease stages were found, with the exception of the control group compared with stage 1 patients; similar results were obtained for FA. ADC values in the cortex and medulla in stage 1-3 patients were both statistically different, similar to the FA values. A significant negative correlation was found between the percentage of glomerulosclerosis and FA in the renal cortex (r =  -0.74), similar to the degree of tubulointerstitial fibrosis with FA in the medulla (r = -0.76). CONCLUSIONS:ADC and FA values are correlated with the degree of renal impairment, the percentage of glomerulosclerosis, and area of interstitial fibrosis. KEY POINTS:• DTI can be used to assess renal function impairment in patients with chronic glomerulonephritis. • ADC and FA values were correlated with tubulointerstitial fibrosis and glomerulosclerosis. • Identification of renal impairment is helpful for timely treatment. • DTI can be used for non-invasive assessment of renal pathology.

译文

目的:探讨DTI是否可以评估慢性肾小球肾炎患者的肾功能损害和病理。
材料与方法:该研究纳入了75名患者和20名健康志愿者。评估肾功能和肾脏活检。对于DTI,执行呼吸触发的冠状EPI序列(TR,1400毫秒; TE,76毫秒;扩散方向,6; NEX,4; b值,0和600 s / mm2;切片厚度,6 mm,无相交间隙)。计算肾ADC和FA值,并在各组之间进行比较。评估了ADC / FA与组织病理学之间的相关性。
结果:ADC值随阶段增加而降低。发现在不同疾病阶段的肾实质中ADC的差异,对照组与1期患者相比有所不同。 FA的结果相似。 1-3期患者皮质和髓质中的ADC值均在统计学上不同,类似于FA值。在肾皮质中的肾小球硬化百分比与FA之间存在显着的负相关性(r = 0.7 -0.74),类似于髓质中FA引起的肾小管间质纤维化程度(r = -0.76)。
结论:ADC和FA值与肾功能不全的程度,肾小球硬化的百分比和间质纤维化的面积有关。
要点:•DTI可用于评估慢性肾小球肾炎患者的肾功能损害。 •ADC和FA值与肾小管间质纤维化和肾小球硬化相关。 •识别肾功能不全有助于及时治疗。 •DTI可用于肾脏病理的非侵入性评估。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录