Twenty-four antimicrobial drugs were examined for rapidity of onset and magnitude of bactericidal activity against selected strains of Clostridium perfringens. Ceftriaxone, imipenem, metronidazole, mezlocillin, penicillin G, piperacillin, and teicoplanin reduced colony counts by at least 3 log10 units within 2-4 h after exposure. Clindamycin, fluoroquinolones, josamycin, and tetracycline caused delayed kill (greater than or equal to 99.9% reduction of viable counts at 4-22 h after exposure). Chloramphenicol and rifampin lacked bactericidal activity against 2 of 4 strains, whereas erythromycin, fusidic acid, and fosfomycin (with added glucose-6-phosphate) were merely inhibitory for all 4 strains. Imipenem and penicillin G were combined with 9 and 12 antimicrobial drugs, respectively. Essentially all drug combinations yielded indifferent effects; only penicillin G plus doxycycline resulted in an antagonistic effect against C. perfringens.

译文

:检查了二十四种抗微生物药物对产气荚膜梭状芽孢杆菌某些菌株的起效速度和杀菌活性的大小。头孢曲松,亚胺培南,甲硝唑,美洛西林,青霉素G,哌拉西林和替考拉宁在暴露后2-4小时内可将菌落数减少至少3 log10个单位。克林霉素,氟喹诺酮,乔沙霉素和四环素引起延迟杀灭(暴露后4-22 h内存活计数减少等于或大于99.9%)。氯霉素和利福平对4个菌株中的2个缺乏杀菌活性,而红霉素,夫西地酸和磷霉素(添加了6-磷酸葡萄糖)仅对全部4个菌株具有抑制作用。亚胺培南和青霉素G分别与9种和12种抗菌药物合用。基本上所有药物组合均产生无关紧要的作用。仅青霉素G加强力霉素可导致对产气荚膜梭菌的拮抗作用。

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