The objective of this study was to prepare a 72 h-release formulation of silybin (72 h-SLB) using a combination of solid dispersion, gel matrix and porous silica nanoparticles (PSNs) and to investigate the in vitro/in vivo correlations (IVIVCs). The results of scanning electron microscopy and N(2) adsorption demonstrated that empty PSNs possessed a spherical shape, a highly porous structure, a large specific surface area (385.89 ± 1.12 m(2)/g) and a small pore size (2.74 nm on average). The in vitro dissolution profiles of both 72 h-SLB and silybin-loaded PSNs in different concentrations (0.01, 0.06 and 0.08M) of Na(2)CO(3) solutions revealed that 0.06 M Na(2)CO(3) solution was the optimal medium in which silybin could be released from 72 h-SLB with first-order release kinetics and from PSNs with Higuchi kinetics. Furthermore, the IVIVCs of 72 h-SLB and silybin-loaded PSNs in beagle dogs were also established. Using 0.06 M Na(2)CO(3) solution as the in vitro dissolution medium, a good linear relationship could be achieved for both 72 h-SLB and silybin-loaded PSNs. The findings support the fact that the 72 h-SLB (consisting of solid dispersion, regular gel matrix and PSNs) together with Na(2)CO(3) solution as an in vitro dissolution medium can be developed into a promising formulation for poorly soluble drugs, which enjoys a good IVIVC.

译文

:这项研究的目的是使用固体分散体,凝胶基质和多孔二氧化硅纳米粒子(PSN)的组合制备水飞蓟宾(72 h-SLB)的72 h释放制剂,并研究体内/体外相关性( IVIVC)。扫描电子显微镜和N(2)吸附的结果表明,空的PSN具有球形,高度多孔的结构,较大的比表面积(385.89±1.12 m(2)/ g)和较小的孔径(2.74 nm)一般)。 Nah(2)CO(3)解决方案中不同浓度(0.01、0.06和0.08M)的72 h-SLB和水飞蓟宾加载的PSNs的体外溶出曲线显示0.06 M Na(2)CO(3)解决方案是最佳的培养基,其中水飞蓟宾可以从72 h-SLB中以一级释放动力学释放,而从PSN中以Higuchi动力学释放。此外,还建立了比格犬中72 h-SLB和水飞蓟宾的PSN的IVIVC。使用0.06 M Na(2)CO(3)解决方案作为体外溶出介质,可以为72 h-SLB和水飞蓟宾加载的PSNs都实现良好的线性关系。这些发现支持以下事实:72 h-SLB(由固体分散体,规则的凝胶基质和PSN组成)与Na(2)CO(3)解决方案一起作为体外溶出介质,可以开发为溶解性较差的有前途的制剂药物,享有良好的IVIVC。

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