We have proposed a transdermal biolistic method to accelerate a powder formulation of drugs to penetrate human skin for the treatment of a range of diseases. One of the key issues for designing and evaluating transdermal biolistic system is ensuing that the powder drugs are delivered into the skin with a controllable velocity range and spatial distribution. The aerodynamics of supersonic nozzles and performance of the delivery system were initially studied, mainly analytically and experimentally. In this paper, computational fluid dynamics is utilized to characterize two existing prototype devices, in order to further investigate the transient gas and particle dynamics in their supersonic nozzles. To validate the implemented numerical approach, calculated pressure histories, two-dimensional flow structures and particle velocity distributions are made and compared with the reported experimental measurements. The key features of gas dynamics, gas-particle interaction and performance of the prototype transdermal biolistics are discussed and interpreted.

译文

:我们提出了一种透皮生物弹射法,以加速药物粉末制剂渗透人体皮肤,从而治疗多种疾病。设计和评估透皮生物弹药系统的关键问题之一是确保将粉末药物以可控制的速度范围和空间分布传递到皮肤中。最初主要是通过分析和实验研究超音速喷嘴的空气动力学和输送系统的性能。在本文中,利用计算流体动力学来表征两个现有的原型设备,以进一步研究其超音速喷嘴中的瞬态气体和粒子动力学。为了验证已实施的数值方法,计算了压力历史,二维流动结构和颗粒速度分布,并将其与报告的实验测量结果进行了比较。讨论并解释了气体动力学,气体-颗粒相互作用和原型透皮生物弹性能的关键特征。

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