The association of doxycycline and periodontal treatment in non-controlled diabetes mellitus (DM) has shown positive results on clinical and metabolic parameters. Antimicrobial photodynamic therapy (aPDT) is a local and painless antimicrobial treatment that can be applied in periodontal treatment without systemic risks. The aim of this study was to evaluate the potential improvement of aPDT on clinical and metabolic effects in patients with type 2 diabetes mellitus in conjunction with nonsurgical periodontal treatment plus doxycycline. Thirty patients with type 2 diabetes and diagnosis of chronic periodontitis were treated with scaling and root planning (SRP; N = 15) or SRP plus phenothiazine chloride photosensitizer-induced aPDT (SRP + aPDT, N = 15). Patients of both groups took doxycycline (100 mg/day) for 2 weeks and plaque index, bleeding on probe (BOP), probing pocket depth (PPD), suppuration, clinical attachment level (CAL), and glycated hemoglobin levels (HbA1c) were measured at baseline and 3 months after therapy. An improvement in clinical parameters such as PPD, CAL, S, and BOP between groups was observed but without statistical significance (p > 0.05). Intragroup analysis showed a significant reduction of HbA1c (8.5 ± 0.9 to 7.5 ± 0.1, p < 0.01) in the SRP + aPDT group. The differences of HbA1c between baseline and 3 months were greater for the SRP + aPDT (11.4 %) than SRP (10 %) (0.87 ± 0.9 and 0.4 ± 0.84 respectively; p < 0.05). A single application of the aPDT as an adjunct to periodontal treatment did not show additional benefits in the clinical parameters but resulted in a slight greater decrease in HbA1c.

译文

:在非控制性糖尿病(DM)中,强力霉素与牙周治疗的关联在临床和代谢参数方面显示出积极的结果。抗菌素光动力疗法(aPDT)是一种局部且无痛的抗菌素疗法,可用于牙周治疗而无系统性风险。这项研究的目的是评估aPDT对2型糖尿病患者结合非手术牙周治疗加强力霉素的临床和代谢作用的潜在改善作用。 30例2型糖尿病并诊断为慢性牙周炎的患者接受了结垢和牙根计划(SRP; N = 15)或SRP加上吩噻嗪氯化物光敏剂诱导的aPDT(SRP aPDT,N = 15)。两组患者均接受强力霉素(100 mg /天)治疗2周,其斑块指数,探针出血(BOP),探查袋深度(PPD),化脓,临床依从水平(CAL)和糖化血红蛋白水平(HbA1c)均为在基线和治疗后3个月进行测量。两组之间的临床参数如PPD,CAL,S和BOP均有改善,但无统计学意义(p> 0.05)。组内分析显示,SRP aPDT组的HbA1c显着降低(8.5±0.9至7.5±0.1,p <0.01)。对于SRP aPDT,基线和3个月之间HbA1c的差异(11.4%)大于SRP(10%)(分别为0.87±0.9和0.4±±0.84; p <0.05)。单独应用aPDT作为牙周治疗的辅助手段并未在临床指标上显示出其他益处,但导致HbA1c的下降幅度更大。

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