Tetracycline and doxycycline are commonly used antibiotics in acne treatment during puberty in humans. The long-term effect of these antibiotics on male reproductive tract development has not been fully elucidated. For this reason we tested the effect of antibiotics on the reproductive parameters of mice males during puberty with the therapeutic dose used in humans, and with lower and higher doses. The outbred mouse strain CD1 with higher heterozygosity was exposed for 14 days at puberty. Adult males at the age of 70 days were used for the measurements. We observed a significant decrease in anogenital distance and thickness of the seminiferous epithelium in the treated animals. Pathological changes in the testes had an impact on sperm quality; a higher number of sperm positively stained with Annexin V and TUNEL and a lower number of acrosome-intact sperm was detected. In conclusion, the treatment of male mice with antibiotics in puberty led to long-lasting effects on reproductive organs and spermatozoa in adult males.

译文

:四环素和强力霉素是人类青春期痤疮治疗中常用的抗生素。这些抗生素对男性生殖道发育的​​长期影响尚未完全阐明。因此,我们以人类使用的治疗剂量以及更高和更低的剂量测试了青春期抗生素对雄性小鼠生殖参数的影响。具有较高杂合度的远交小鼠品系CD1在青春期暴露14天。使用70天的成年男性进行测量。我们观察到治疗动物中肛门生殖器距离和生精上皮厚度的显着减少。睾丸的病理变化对精子质量有影响;被膜联蛋白V和TUNEL阳性染色的精子数量较多,而顶体完整精子的数量较少。总之,在青春期用抗生素治疗雄性小鼠可对成年雄性动物的生殖器官和精子产生长期影响。

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