Two-dimensional and Doppler echocardiographic studies and a hemodynamic investigation were performed during dipyridamole testing in 42 subjects (13 control subjects and 29 patients with coronary artery disease [CAD]), to evaluate the ability of dipyridamole Doppler echocardiography in identifying patients with ischemic left ventricular dysfunction. In the control group, after dipyridamole infusion, Doppler-derived parameters increased significantly from baseline (p less than 0.001). In patients with CAD, peak flow velocity, flow velocity integral and stroke volume failed to increase after dipyridamole infusion (0.89 +/- 0.21 to 0.85 +/- 0.18 m/s, difference not significant; 14 +/- 3 to 12 +/- 4 cm, difference not significant, and 56 +/- 13 to 50 +/- 14 ml/beat, p less than 0.05, respectively). Heart rate, rate pressure product, systemic vascular resistance and mean right atrial pressure had similar variations in the 2 groups. Changes in the 3 Doppler-derived parameters are closely related to the variations of peak positive dP/dt, stroke volume (thermodilution) and left ventricular end-diastolic pressure and are closely related to the coronary angiography jeopardy score and to the appearance of wall motion abnormalities. Thus, by combining Doppler and 2-dimensional echocardiography, dipyridamole-induced myocardial ischemia may be detected in a high percentage of CAD patients, providing a sensitive tool for identifying patients with high-risk coronary artery anatomy.

译文

:对双嘧达莫进行了二维和多普勒超声心动图研究,并在42名受试者(13例对照受试者和29名冠心病[CAD])中进行了血流动力学研究,以评估双嘧达莫多普勒超声心动图对缺血性左心病患者的识别能力心室功能不全。在对照组中,双嘧达莫输注后,多普勒衍生的参数较基线显着增加(p小于0.001)。在患有冠心病的患者中,双嘧达莫输注后峰值流速,流速积分和每搏量未能增加(0.89 /-0.21至0.85 /-0.18 m / s,差异不显着; 14 /-3至12 /-4 cm,差异不显着,分别为56 /-13至50 /-14 ml / beat,p分别小于0.05)。在两组中,心率,速率压力乘积,全身血管阻力和平均右心房压力具有相似的变化。 3个多普勒衍生参数的变化与峰值dP / dt,中风量(热稀释)和左室舒张末期压力的变化密切相关,并且与冠状动脉造影危险分数和壁运动的出现密切相关。异常。因此,通过将多普勒和二维超声心动图相结合,可以在高百分比的CAD患者中检测出双嘧达莫引起的心肌缺血,从而为识别具有高风险冠状动脉解剖结构的患者提供了灵敏的工具。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录