Five new furanoditerpenoids, epi-8-hydroxycolumbin (1), fibaruretin B (2), C (3), E (5), and F (6), were isolated from the stems of Fibraurea tinctoria, as well as fibaruretin D (4) from the natural source for the first time, and 39 known compounds. The structures (1-6) were elucidated on the basis of spectroscopic analysis. All the isolated furanoditerpenoids (1-16) were examined for their in vitro activity and some were in vivo anti-inflammatory activity. Compounds 8 and 9 showed significant anti-inflammatory action administered at a dose of 100mg/kg of reducing carrageenan mice paw edema, whereas compound 7, 9, 10, 14, and 16 were more potent to inhibit NO production. The inhibitory effects of these compounds are dose-dependent (1-4 microg/ml).

译文

:从Fibraurea tinctoria和fibaruretin D的茎中分离出五种新的呋喃二萜,epi-8-hydroxycolumbin(1),fibaruretin B(2),C(3),E(5)和F(6)。 (4)首次从天然来源中获得39种已知化合物。在光谱分析的基础上阐明了结构(1-6)。检查所有分离的呋喃二萜类化合物(1-16)的体外活性,其中一些具有体内抗炎活性。化合物8和9显示出以100 mg / kg的角叉菜胶减少鼠爪水肿的剂量给予的显着抗炎作用,而化合物7、9、10、14和16更有效地抑制了NO的产生。这些化合物的抑制作用是剂量依赖性的(1-4微克/毫升)。

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