Two new quinolizidine-based alkaloids (2 and 12), along with ten known ones (1, 3-11) were isolated from the roots of S. tonkinensis. Their structures were determined by spectroscopic data (including NMR, MS, IR, and UV), X-ray single crystal diffraction, electronic circular dichroism analyses (ECD), and comparing with related literatures. Compounds 1, 3-12 at non-toxic concentrations exhibited potent anti-inflammatory activities according to in vitro and in vivo anti-inflammatory tests. Among them, (-)-anagyrine (4), sophocarpine (8), 14β-hydroxymatrine (10), and 7β-sophoramine (12) showed more potent in vitro anti-inflammatory activities, and 5α,14β-dihydroxymatrine (2), (-)-anagyrine (4), sophocarpine (8), and 5α-hydroxymatrine (9) exhibited better in vivo anti-inflammatory effects.

译文

:从S. tonkinensis的根中分离出两种新的基于喹喔啉的生物碱(2和12),以及十种已知的生物碱(1、3-11)。它们的结构由光谱数据(包括NMR,MS,IR和UV),X射线单晶衍射,电子圆二色性分析(ECD)以及与相关文献进行比较来确定。根据体外和体内抗炎试验,无毒浓度的化合物1、3-12表现出有效的抗炎活性。其中,(-)-Anagyrine(4),Sophocarpine(8),14β-hydroxymatrine(10)和7β-sophoramine(12)表现出更强的体外抗炎活性,而5α,14β-dihydroxymatrine(2) ,(-)-Anagyrine(4),Sophocarpine(8)和5α-hydroxymatrine(9)表现出更好的体内抗炎作用。

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