BACKGROUND & AIMS: :With an increasing number of lipophilic drugs under development, homolipids and heterolipids have gained renewed interests as excipients for oral drug delivery systems. Oral administration has many advantages for chronic drug therapy. It is relatively safe, convenient for the patient and allows self administration. This article is not intended to review the broad area of lipid-based vehicle for oral drug delivery comprehensively. The rationale behind choosing lipids materials for pharmaceutical dosage forms and their applications is discussed. It also comments on the methods for monitoring the physicochemical properties of vehicles and formulations and describes a range of pharmacopoeial excipients suitable for these purposes. The excipients selected here are pharmacopoeial in European Pharmacopoeia 4th Ed., United States Pharmacopoeia 24th Ed./National Formulary 19th Ed. and Japanese Pharmacopoeia 13th Ed. or are drafted in Pharmaeuropa and Pharmacopoeial Forum. Widening availability of lipidic excipients with specific characteristics offer flexibility of application with respect to improving the bioavailability of poorly water-soluble drugs and manipulating release profiles.

背景与目标： ：随着越来越多的亲脂性药物的发展，同型和异型脂作为口服药物输送系统的赋形剂重新引起了人们的兴趣。口服给药对于慢性药物治疗具有许多优点。它相对安全，方便患者并且可以自我管理。本文无意全面回顾用于口服药物递送的基于脂质的媒介物的广阔领域。讨论了选择用于药物剂型的脂质材料及其应用的原理。它还对监测媒介物和制剂的理化性质的方法进行了评论，并介绍了适用于这些目的的一系列药典赋形剂。在此选择的赋形剂在《欧洲药典》第4版，《美国药典》第24版/《国家配方》第19版中是药典。和日本药典第13版。或在Pharmae​​uropa和Pharmacopoeial论坛中起草。具有特定特征的脂质赋形剂的可利用性的增加在改善水溶性差的药物的生物利用度和操纵释放特性方面提供了应用的灵活性。