Peripheral artery disease (PAD) is a result of the atherosclerotic narrowing of blood vessels to the extremities, and the subsequent tissue ischemia can lead to the up-regulation of angiogenic growth factors and formation of new vessels as a recovery mechanism. Such formation of new vessels can be evaluated with various non-invasive molecular imaging techniques, where serial images from the same subjects can be obtained to allow the documentation of disease progression and therapeutic response. The most commonly used animal model for preclinical studies of PAD is the murine hindlimb ischemia model, and a number of radiotracers have been investigated for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of PAD. In this review article, we summarize the PET/SPECT tracers that have been tested in the murine hindlimb ischemia model as well as those used clinically to assess the extremity blood flow.

译文

:周围动脉疾病(PAD)是动脉粥样硬化狭窄至四肢的结果,随后的组织缺血可导致血管生成生长因子的上调并形成新血管作为恢复机制。可以使用各种非侵入性分子成像技术来评估这种新血管的形成,其中可以获得来自相同受试者的系列图像,从而可以记录疾病的进展和治疗反应。用于PAD临床前研究的最常用动物模型是鼠后肢缺血模型,并且已经对PAD的正电子发射断层扫描(PET)和单光子发射计算机断层扫描(SPECT)成像研究了许多放射性示踪剂。在这篇综述文章中,我们总结了已经在鼠后肢缺血模型中测试过的PET / SPECT示踪剂,以及在临床上用于评估肢体血流的示踪剂。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录