As an initial subdeficient status of zinc, considered as an essential antioxidant trace element, is frequent in burned patients, we aim to assess the effects of low zinc dietary intakes on burn-induced oxidative stress, in an animal model. After 8 weeks of conditioning diets containing 80 ppm (control group) or 10 ppm of zinc (depleted group), Wistar rats were 20% TBSA burned and sampled 1-10 days after injury. Kinetic evolutions of zinc status, plasma oxidative stress parameters, and antioxidant enzymes were also studied in blood and organs. The zinc-depleted diet induced, before injury, a significant decrease in zinc bone level and the increase of oxidative stress markers without stimulation of antioxidant enzyme activity. After burn, more markedly in zinc depleted animals than in controls, zinc levels decreased in plasma and bone, while increasing in liver. The decrease of thiol groups and GSH/GSSG ratio and the depression of GPx activity in liver are also moderately emphasized. Nevertheless, depleted zinc status could not be considered as determining for oxidative damages after burn injury. Further investigations must also be done to enlighten the mechanism of beneficial effects of zinc supplementation reported in burned patients.

译文

:由于烧伤患者经常缺锌,认为锌是人体必需的抗氧化剂微量元素,因此在动物模型中,我们旨在评估低锌饮食摄入对烧伤诱导的氧化应激的影响。经过8周的含有80 ppm(对照组)或10 ppm锌(贫化组)的饮食,Wistar大鼠被烧伤20%TBSA,并在受伤后1-10天取样。还研究了血液和器官中锌状态,血浆氧化应激参数和抗氧化酶的动力学演化。缺锌饮食在受伤前会导致锌骨水平显着下降和氧化应激标记物的增加,而不会刺激抗氧化酶的活性。烧伤后,缺锌动物中的锌含量明显高于对照组,血浆和骨骼中的锌含量下降,而肝脏中的锌含量上升。肝脏中硫醇基团和GSH / GSSG比值的降低以及GPx活性的降低也得到了适当的强调。然而,锌的贫化状态不能被认为是烧伤后氧化损伤的决定因素。还必须进行进一步的研究,以启发烧伤患者中锌补充的有益作用机理。

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