We prospectively evaluated the efficacy and safety of a low concentrate citrate lock versus heparin lock in permanent single lumen hemodialysis catheters. The frequency of clot formation, complete catheter occlusion, flow problems and the use of urokinase as well as catheter infection episodes were monitored during 1370 dialysis sessions in 19 patients, randomised in two study groups. There was a significantly higher number of dialysis sessions with clot formation in the citrate group but regarding the need for urokinase bolus or infusion, complete obstruction of the catheter or local infections, there were no statistically significant differences between groups. The higher incidence of clotting in the citrate locked catheters had no repercussion on dialysis efficiency, effective blood flow or on the use of thrombolytic therapy. We found that low concentrate citrate is as safe as heparin for long-term interdialytic anticoagulation of permanent single lumen hemodialysis catheters but is more efficient from a pharmaco-economic viewpoint.

译文

:我们前瞻性评估了永久性单腔血液透析导管中低浓度柠檬酸盐锁与肝素锁的疗效和安全性。在19个患者的1370次透析期间,对血凝块形成的频率,完全的导管阻塞,流量问题和尿激酶的使用以及导管感染的发作进行了监测,并随机分为两个研究组。柠檬酸盐组的透析时间明显增加,但有凝块形成,但考虑到需要尿激酶推注或输注,完全阻塞导管或局部感染,两组之间在统计学上没有显着差异。柠檬酸盐锁定导管中较高的凝结发生率对透析效率,有效血流量或溶栓治疗的使用没有影响。我们发现低浓度的柠檬酸盐对永久性单腔血液透析导管的长期透析间抗凝治疗与肝素一样安全,但从药物经济学角度来看更有效。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录