Cardiovascular disease continues to be the foremost cause of morbidity and mortality in dialysis patients. Compared with the general population, dialysis patients suffer from an accelerated disease course that is, at least in part, resistant to conventional therapy. While there are a myriad of potential explanations for this resistance, derangements in lipid metabolism probably play an important role. Here, we discuss the significance of altered lipid metabolism in uremia, such as oxidative lipoprotein modification and the pathophysiology of adipose tissue; limitations of conventional approaches to dyslipidemia such as statin therapy and traditional lipid profiles; and areas of investigation with potential for new therapy, such as reverse cholesterol transport.

译文

:心血管疾病仍然是透析患者发病和死亡的首要原因。与普通人群相比,透析患者的疾病病程加速,至少部分对常规治疗有抵抗力。尽管对此耐药性有许多潜在的解释,但脂质代谢紊乱可能起着重要作用。在这里,我们讨论了尿毒症中脂质代谢改变的重要性,例如氧化脂蛋白的修饰和脂肪组织的病理生理学。常规血脂异常方法的局限性,例如他汀类药物疗法和传统的脂质谱;以及可能进行新疗法(例如胆固醇逆向转运)的研究领域。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录