Bacterial populations exhibit a range of metabolic states influenced by their environment, intra- and interspecies interactions. The identification of bacterial metabolic states and transitions between them in their native environment promises to elucidate community behavior and stochastic processes, such as antibiotic resistance acquisition. In this work, we employ two-photon fluorescence lifetime imaging microscopy (FLIM) to create a metabolic fingerprint of individual bacteria and populations. FLIM of autofluorescent reduced nicotinamide adenine dinucleotide (phosphate), NAD(P)H, has been previously exploited for label-free metabolic imaging of mammalian cells. However, NAD(P)H FLIM has not been established as a metabolic proxy in bacteria. Applying the phasor approach, we create FLIM-phasor maps of Escherichia coli, Salmonella enterica serovar Typhimurium, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus epidermidis at the single cell and population levels. The bacterial phasor is sensitive to environmental conditions such as antibiotic exposure and growth phase, suggesting that observed shifts in the phasor are representative of metabolic changes within the cells. The FLIM-phasor approach represents a powerful, non-invasive imaging technique to study bacterial metabolism in situ and could provide unique insights into bacterial community behavior, pathology and antibiotic resistance with sub-cellular resolution.

译文

:细菌种群表现出一系列受其环境,种内和种间相互作用影响的代谢状态。细菌代谢状态及其在自然环境中之间的过渡的鉴定有望阐明社区行为和随机过程,例如获得抗生素抗药性。在这项工作中,我们采用双光子荧光寿命成像显微镜(FLIM)来创建单个细菌和种群的代谢指纹。自发荧光还原烟酰胺腺嘌呤二核苷酸(磷酸)的FLIM NAD(P)H先前已被用于哺乳动物细胞的无标记代谢成像。但是,NAD(P)H FLIM尚未被确定为细菌中的代谢替代物。应用相量方法,我们在单个细胞和群体水平上创建了大肠杆菌,肠炎沙门氏菌血清型鼠伤寒杆菌,铜绿假单胞菌,枯草芽孢杆菌和表皮葡萄球菌的FLIM相量图。细菌相量对环境条件敏感,例如抗生素暴露和生长期,这表明所观察到的相量变化代表细胞内代谢变化。 FLIM相量方法代表了一种强大的,非侵入性的成像技术,可用于原位研究细菌代谢,并且可以通过亚细胞分辨率为细菌群落行为,病理学和抗生素耐药性提供独特的见解。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录