Autologous fat grafting for breast augmentation has faced some historical hurdles. However, in recent years it has been gaining acceptance from the medical community. This prospective, nonrandomized open-label study of 20 Japanese women supports the use of autologous fat grafting in breast augmentation and explores enhancement of fat graft tissue with autologous adipose-derived regenerative cells (ADRCs). After adipose harvesting using syringe liposuction, the tissue is processed in the Celution 800 System(®), which washes the graft and isolates ADRCs. The average cells per gram of harvested adipose tissue was 3.42 × 10(5), and the mean cell viability measured using an automated cell counting system before graft delivery was 85.3%. All patients demonstrated improvement in circumferential breast measurement (BRM) from their baseline state, and breast measurements were stable by 3 months after surgery. The mean BRM 9 months after surgery had increased 3.3 cm from preoperative measurements. Through 9 months, overall physician satisfaction was 69% and patient satisfaction was 75%. No serious or unexpected adverse events were reported, and the procedure was safe and well tolerated in all patients. Postoperative cyst formation was seen in two patients. These prospective results demonstrate that ADRC-enriched fat grafts processed with a closed automated system maintain high cell viability and that the procedure is safe and effective, with all patients showing improvement after a single treatment.

译文

自体脂肪移植隆胸面临一些历史障碍。但是,近年来,它已获得医学界的认可。这项针对20名日本女性的前瞻性,非随机开放标签研究支持在隆胸中使用自体脂肪移植,并探索用自体脂肪来源的再生细胞 (adrc) 增强脂肪移植组织。使用注射器吸脂进行脂肪采集后,在cellution 800系统中处理组织 (®),洗涤移植物并分离ADRCs。每克收获的脂肪组织的平均细胞为3.42 × 10(5),并且85.3% 在移植物递送之前使用自动细胞计数系统测量的平均细胞活力。所有患者的周围乳房测量 (BRM) 均从基线状态改善,并且在术后3个月时乳房测量稳定。手术后9个月的平均BRM与术前测量相比3.3厘米增加。通过9个月,医生的总体满意度69%,患者满意度75%。未报告严重或意外的不良事件,所有患者均安全且耐受性良好。两名患者术后出现囊肿形成。这些前瞻性结果表明,用封闭的自动化系统处理的富含ADRC的脂肪移植物可保持较高的细胞活力,并且该过程是安全有效的,所有患者在单次治疗后均显示出改善。

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