OBJECTIVE:Recent studies have demonstrated that 1,3-diacylglycerol (1,3-DAG) has several metabolic advantages over triacylglycerol (TAG) in humans and in animal models despite both oils having a similar fatty acid composition. In our current study, we have examined the effects of long-term feeding of a 1,3-DAG-rich oil on the dyslipidemia and atherosclerosis in the experimental model of the diabetic apolipoprotein E (apoE)-deficient mouse that develops accelerated atherosclerosis. METHODS AND RESULTS:Diets containing 1,3-DAG-rich oil or TAG oil were administered to control non-diabetic apoE-dificient and diabetic apoE-deficient mice for 20 weeks. In diabetic apoE-deficient mice, 1,3-DAG reduced the extent of atherosclerotic lesions in the aortic arch and thoracic aorta by 37 and 44%, respectively, compared to TAG. Further, in diabetic apoE-deficient mice, plasma total cholesterol and triglyceride levels were significantly lower in the 1,3-DAG-fed group than in the TAG-fed group. This occurred partially through an apparent reduction in the size of triglyceride-rich lipoproteins but not apparently by reducing the number of lipoprotein particles. By contrast the control non-diabetic apoE-deficient mice showed no differential responses to the type of oil at least over 20 weeks. CONCLUSIONS:We have demonstrated that dietary 1,3-DAG-rich oil reduced atherosclerosis in diabetic apoE-deficient mice, and was associated with reduction in plasma cholesterol especially within larger triglyceride-rich lipoproteins.

译文

目的:最近的研究表明,尽管两种油具有相似的脂肪酸组成,但在人和动物模型中,1,3-二酰基甘油(1,3-DAG)比三酰基甘油(TAG)具有若干代谢优势。在我们当前的研究中,我们在糖尿病性载脂蛋白E(apoE)缺陷型小鼠模型中,长期食用富含1,3-DAG的油对血脂异常和动脉粥样硬化的影响,这种小鼠会加速动脉粥样硬化。
方法和结果:给予含1,3-DAG丰富的油脂或TAG油脂的饮食,以控制非糖尿病apoE缺乏和糖尿病apoE缺乏的小鼠20周。在糖尿病apoE缺陷型小鼠中,与TAG相比,1,3-DAG分别将主动脉弓和胸主动脉的动脉粥样硬化病变程度降低了37%和44%。此外,在糖尿病apoE缺陷型小鼠中,1,3-DAG喂养组的血浆总胆固醇和甘油三酯水平显着低于TAG喂养组。这部分是由于富含甘油三酸酯的脂蛋白大小的明显减少而发生的,而不是由于减少脂蛋白颗粒的数量而明显发生的。相比之下,对照非糖尿病apoE缺陷型小鼠至少在20周内未显示出对油脂类型的差异反应。
结论:我们已经证明,富含饮食的1,3-DAG的油可以减少糖尿病apoE缺乏症小鼠的动脉粥样硬化,并且与血浆胆固醇的降低有关,尤其是在较大的富含甘油三酸酯的脂蛋白中。

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