Chronic hyperglycaemia in diabetes leads to the overproduction of free radicals and evidence is increasing that these contribute to the development of diabetic nephropathy. Among the spices, turmeric (Curcuma longa) is used as a flavouring and colouring agent in the indian diet every day and is known to possess anti-oxidant properties. The present study was designed to examine the effect of curcumin, a yellow pigment of turmeric, on renal function and oxidative stress in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by a single intraperitoneal injection of STZ (65 mg/kg) in rats. Four weeks after STZ injection, rats were divided into four groups, namely control rats, diabetic rats and diabetic rats treated with curcumin (15 and 30 mg/kg, p.o.) for 2 weeks. Renal function was assessed by creatinine, blood urea nitrogen, creatinine and urea clearance and urine albumin excretion. Oxidative stress was measured by renal malonaldehyde, reduced glutathione and the anti-oxidant enzymes superoxide dismutase and catalase. Streptozotocin-injected rats showed significant increases in blood glucose, polyuria and a decrease in bodyweight compared with age-matched control rats. After 6 weeks, diabetic rats also exhibited renal dysfunction, as evidenced by reduced creatinine and urea clearance and proteinuria, along with a marked increase in oxidative stress, as determined by lipid peroxidation and activities of key anti-oxidant enzymes. Chronic treatment with curcumin significantly attenuated both renal dysfunction and oxidative stress in diabetic rats. These results provide confirmatory evidence of oxidative stress in diabetic nephropathy and point towards the possible anti-oxidative mechanism being responsible for the nephroprotective action of curcumin.

译文

:糖尿病中的慢性高血糖症导致自由基的过度产生,并且越来越多的证据表明这些自由基有助于糖尿病性肾病的发展。在香料中,姜黄(姜黄)每天在印度饮食中用作调味剂和着色剂,并且已知具有抗氧化特性。本研究旨在检查姜黄素(一种姜黄黄色素)对链脲佐菌素(STZ)诱导的糖尿病大鼠肾功能和氧化应激的影响。在大鼠中通过腹膜内单次注射STZ(65 mg / kg)诱发糖尿病。注射STZ后四周,将大鼠分为四组,即对照大鼠,糖尿病大鼠和经姜黄素(15和30 mg / kg,口服)治疗2周的糖尿病大鼠。通过肌酐,血液尿素氮,肌酐和尿素清除率以及尿白蛋白排泄评估肾功能。通过肾脏丙二醛,还原型谷胱甘肽和抗氧化酶超氧化物歧化酶和过氧化氢酶来测定氧化应激。与年龄相称的对照大鼠相比,注射链脲佐菌素的大鼠显示血糖,多尿明显增加,体重下降。 6周后,糖尿病大鼠还表现出肾功能不全,这由肌酐和尿素清除率降低和蛋白尿以及氧化应激显着增加所证实,氧化应激由脂质过氧化作用和关键抗氧化酶的活性决定。姜黄素的慢性治疗可显着减轻糖尿病大鼠的肾功能不全和氧化应激。这些结果提供了糖尿病性肾病中氧化应激的确证证据,并指出可能的抗氧化机制负责姜黄素的肾保护作用。

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