BACKGROUND & AIMS:
:Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly skin and joint manifestations affecting approximately 2% of the population. In this second of 5 sections of the guidelines of care for psoriasis, we give an overview of psoriatic arthritis including its cardinal clinical features, pathogenesis, prognosis, classification, assessment tools used to evaluate psoriatic arthritis, and the approach to treatment. Although patients with mild to moderate psoriatic arthritis may be treated with nonsteroidal anti-inflammatory drugs and/or intra-articular steroid injections, the use of disease-modifying antirheumatic drugs, particularly methotrexate, along with the biologic agents, are considered the standard of care in patients with more significant psoriatic arthritis. We will discuss the use of disease-modifying antirheumatic drugs and the biologic therapies in the treatment of patients with moderate to severe psoriatic arthritis.
背景与目标:
银屑病:牛皮癣是一种常见的,慢性,炎性,多系统疾病,主要表现为皮肤和关节表现,约占总人口的2%。在牛皮癣护理指南的5个部分的第二部分中,我们概述了牛皮癣关节炎,包括其主要临床特征,发病机理,预后,分类,用于评估牛皮癣关节炎的评估工具以及治疗方法。尽管轻度至中度银屑病性关节炎患者可以使用非甾体类抗炎药和/或关节内类固醇注射治疗,但将改变病情的抗风湿药(尤其是甲氨蝶呤)与生物制剂一起使用被认为是护理的标准在患有较严重的银屑病关节炎的患者中。我们将讨论在中重度银屑病关节炎患者中使用改变疾病的抗风湿药和生物疗法。