To better explore the clinical heterogeneity of bipolar mood states, we developed a dimensional scale for assessing all mood episodes (depressive, hypomanic, manic, mixed states) using the same tool. The Multidimensional Assessment of Thymic States (MATHYS) (Henry et al., 2008) provides two scores, a total score measuring a level of activation and a sub-score of emotional reactivity. The aim of this study was to establish the appropriate cut-off in total activation versus inhibition and in the emotional reactivity sub-score in bipolar disorders. Patients (n=187) during an acute episode and controls (n=89) filled in the MATHYS. Receiver Operating Characteristic (ROC) curves were obtained to estimate the sensitivity and specificity of the global score and the emotional reactivity sub-score of the MATHYS, in order to differentiate patients from controls. ROC curves showed very satisfactory sensitivity and specificity levels both for the total score and the sub-score of emotional reactivity, thus providing an appropriate cut-off. Concerning the total score between 0 and 200, patients with a score lower than 91 had significant global inhibition and those with a score higher than 109 had significant global activation. Regarding the emotional reactivity sub-score between 0 and 40, patients with a score lower than 16 had significant emotional hyporeactivity and those with a score higher than 24 had significant emotional hyperreactivity. Our results provide cut-offs for the MATHYS to identify patients in an acute phase.

译文

:为了更好地探索双相情感状态的临床异质性,我们开发了一种用于使用同一工具评估所有情绪事件(抑郁,躁狂,躁狂,混合状态)的量表。胸腺状态的多维评估(MATHYS)(Henry等,2008)提供了两个评分,一个总评分用于衡量激活水平,另一个是情感反应分数。这项研究的目的是确定双相情感障碍的总激活与抑制以及情绪反应性亚评分的适当分界。急性发作期间的患者(n = 187)和对照组(n = 89)填写了MATHYS。获得接收者操作特征(ROC)曲线以估计MATHYS总体评分和情绪反应性子评分的敏感性和特异性,以区分患者与对照组。 ROC曲线在总分和情绪反应的亚评分中均显示出非常令人满意的敏感性和特异性水平,因此提供了适当的临界值。关于总分在0到200之间,得分低于91的患者具有显着的总体抑制作用,得分高于109的患者具有显着的全局抑制作用。关于0至40之间的情绪反应分数,得分低于16的患者有明显的情绪低反应性,而得分高于24的患者则有明显的情绪高反应性。我们的结果为MATHYS识别急性期患者提供了界限。

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