The World Health Organization European Region has one of the highest rates of multidrug-resistant tuberculosis (MDR-TB) in the world, resulting in many vulnerable children being exposed each year. Evidence for preventive therapy following MDR-TB exposure is limited and current guidance is conflicting. An internet-based survey was performed to determine clinical practice in this region. Seventy-two clinicians from 25 countries participated. Practices related to screening and decision-making were highly variable. Just over half provided preventive therapy for children exposed to MDR-TB; the only characteristic associated with provision was practice within the European Union (adjusted OR 4.07, 95%CI 1.33-12.5).

译文

:世界卫生组织欧洲区域是世界上耐多药结核病(MDR-TB)发病率最高的国家之一,每年导致许多弱势儿童被暴露。耐多药结核病暴露后进行预防性治疗的证据有限,目前的指导意见相互矛盾。进行了基于互联网的调查,以确定该地区的临床实践。来自25个国家的72名临床医生参加了会议。与筛查和决策有关的做法变化很大。刚刚超过一半的人为患有耐多药结核病的儿童提供了预防性治疗;与规定相关的唯一特征是欧盟内部的惯例(调整后的OR 4.07,95%CI 1.33-12.5)。

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