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A randomized multicenter study was performed in order to investigate the acceptance of a low-dose OC (30 micrograms of ethinyloestradiol and 150 micrograms of desogestrel), using a 9 weeks on and 1 week off schedule (prolonged regimen, n = 198), compared to a traditional 3 weeks on, 1 week off schedule (standard regimen, n = 96). Haemoglobin and blood pressure remained the same in both groups during the study. No significant differences were found in body weight changes between the two groups. There was significantly more breakthrough bleeding and spotting in the group with prolonged regimen than in the group with standard regimen, but both breakthrough bleeding and spotting decreased during the trial. Irregular bleeding was significantly less in women who were already using OC, compared to "new starters." No serious side effects occurred. Significantly more women stopped the trial because of bleeding problems in the group with prolonged regimen, while there were significantly more women who stopped the trial because of headache in the group with standard regimen. After completing 12 months, or after premature withdrawal from the study, each women completed a questionnaire. Sixty-three per cent of the women preferred the studied alternative and twenty-six per cent preferred the traditional OC.

译文

进行了一项随机多中心研究,以研究低剂量OC (30微克乙炔雌二醇和150微克去氧孕烯) 的接受程度,使用9周和1周的休息时间表 (延长方案,n = 198),与传统的3周相比,休息1周 (标准方案,n = 96)。在研究期间,两组的血红蛋白和血压保持不变。两组之间的体重变化没有显着差异。延长方案组的突破性出血和斑点明显多于标准方案组,但在试验期间突破性出血和斑点均减少.与 “新手” 相比,已经使用OC的女性的不规则出血明显减少。没有发生严重的副作用。在延长治疗方案的组中,由于出血问题而终止试验的女性明显更多,而在标准治疗方案的组中,由于头痛而终止试验的女性明显更多。完成12个月后,或过早退出研究后,每位女性都完成了一份问卷。63% 的女性更喜欢研究的替代方案,而26% 的女性更喜欢传统的OC。

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