Cocoa and chocolate contain the tetrahydroisoquinoline alkaloid salsolinol up to a concentration of 25 microg/g. Salsolinol is a dopaminergic active compound which binds to the D(2) receptor family, especially to the D(3) receptor with a K(i) of 0.48+/-0.021 micromol/l. It inhibits the formation of cyclic AMP and the release of beta-endorphin and ACTH in a pituitary cell system. Taking the detected concentration and the pharmacological properties into account, salsolinol seems to be one of the main psychoactive compounds present in cocoa and chocolate and might be included in chocolate addiction.

译文

可可和巧克力含有四氢异喹啉生物碱salsolinol,浓度高达25微克/克。Salsolinol是一种多巴胺能活性化合物,与D(2) 受体家族结合,特别是与D(3) 受体结合,K(i) 为0.48 +/-0.021微摩尔/升。它抑制垂体细胞系统中环状AMP的形成以及 β-内啡肽和ACTH的释放。考虑到检测到的浓度和药理特性,salsolinol似乎是可可和巧克力中存在的主要精神活性化合物之一,可能包括在巧克力成瘾中。

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