The objective of this work was to characterize trends over time in urinary excretion of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) among cigarette smokers in the US. We identified 35 studies presenting data that either reported, or could be converted to, common units of total urinary NNAL excretion as pmol/mg creatinine. The studies spanned 18years, reported urinary NNAL excretion estimates for 61 defined populations, and included a combined total of 3941 study participants. Analyses show that urinary NNAL excretion trends downward with study publication year, and the trend is statistically significant. The trend does not appear to be accounted for by a reduction in cigarettes smoked per day by study participants over the same time period. This trend is consistent with reductions in tobacco specific nitrosamine (TSNA) levels in both cigarette tobacco filler and mainstream cigarette smoke observed over the past decade and with efforts by the tobacco industry and the agricultural community to reduce levels of TSNAs in tobacco and cigarette smoke.

译文

这项工作的目的是描述美国吸烟者中4-(甲基亚硝基氨基)-1-(3-吡啶基)-1-丁醇 (NNAL) 的尿排泄随时间的趋势。我们确定了35项研究,这些研究提供的数据要么报告了,要么可以转换为总尿NNAL排泄的常见单位,即pmol/mg肌酐。这项研究历时18年,报告了61个定义人群的尿NNAL排泄估计值,总共包括3941名研究参与者。分析表明,随着研究发表年份的增加,尿NNAL排泄量呈下降趋势,并且该趋势具有统计学意义。在同一时期,研究参与者每天吸烟的减少似乎并不能解释这种趋势。这一趋势与过去十年中观察到的卷烟烟草填料和主流卷烟烟气中烟草特定亚硝胺 (TSNA) 水平的降低以及烟草业和农业界为降低烟草和卷烟烟气中的TSNA水平而做出的努力是一致的。

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