Pilomatricoma is a distinctive tumor characterized by a dual population of proliferating basophilic cells and diagnostic shadow cells, believed to arise from the hair matrix. The normal hair matrix undergoes defined cycles of growth (anagen), regression (catagen), and resting (telogen) that are regulated by programmed cell death (apoptosis). bcl-2 is a proto-oncogene that helps to suppress apoptosis in both benign and malignant tumors. In addition, both apoptosis and bel-2 are critical factors in normal hair follicle development. In order to clarify the role of bcl-1, we used immunohistochemical means to study 10 cases of histologically proven pilomatricoma for bcl-2 expression. The study design included both positive and negative controls. All of the pilomatricomas in our series were strongly decorated by bcl-2 immunostaining. Based on our findings of increased bcl-2 staining, we concluded that the faulty suppression of apoptosis contributes to the pathogenesis of pilomatricoma.

译文

毛瘤瘤是一种独特的肿瘤,其特征是增殖的嗜碱性细胞和诊断阴影细胞的双重群体,据信它们是由毛发基质引起的。正常的头发基质经历了由程序性细胞死亡 (凋亡) 调节的生长 (anagen),回归 (catagen) 和静息 (telogen) 周期。bcl-2是一种原癌基因,有助于抑制良性和恶性肿瘤的细胞凋亡。此外,细胞凋亡和bel-2都是正常毛囊发育的关键因素。为了阐明bcl-1的作用,我们使用免疫组织化学手段研究了10例经组织学证实的毛瘤bcl-2表达。研究设计包括阳性和阴性对照。我们系列中的所有绒毛瘤均通过bcl-2免疫染色强烈修饰。根据我们对bcl-2染色增加的发现,我们得出结论,对细胞凋亡的错误抑制有助于毛瘤的发病机理。

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