The aetiology of adolescent idiopathic scoliosis (AIS) is still unknown despite many years of research effort. Theories on AIS's aetiology have included mechanical, hormonal, metabolic, neuromuscular, growth, and genetic abnormalities. Amongst these, some factors may be epiphenomena rather than the cause itself. Other factors may even contribute to curve progression, rather than curve initiation. Current views maintain that AIS is a multifactorial disease with genetic predisposing factors [Lowe et al. in J Bone Joint Surg [Am] 82:1157-1168, 2000]. With improvements in diagnostic methods, imaging and genomics, there has been considerable recent work on aetiology. This review aims to bring readers up-to-date with the latest developments in scoliosis research.

译文

尽管经过多年的研究,青少年特发性脊柱侧凸 (AIS) 的病因仍然未知。AIS病因学的理论包括机械,激素,代谢,神经肌肉,生长和遗传异常。其中,某些因素可能是现象,而不是原因本身。其他因素甚至可能导致曲线进展,而不是曲线启动。目前的观点认为,AIS是具有遗传易感因素的多因素疾病 [Lowe等人在J骨关节外科 [Am] 82:1157-1168,2000]。随着诊断方法,影像学和基因组学的改进,最近在病因学方面开展了大量工作。这篇综述旨在使读者了解脊柱侧弯研究的最新进展。

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