Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of the four major colony-stimulating factors (CSFs) that regulate hematopoiesis. GM-CSF can stimulate a single bone marrow stem cell to proliferate and differentiate into mature neutrophils, eosinophils, granulocytes or macrophages. The outcome of recent clinical trials indicates that GM-CSF has the prospect of being clinically effective in augmenting the recovery of hematopoiesis in recipients of autologous bone marrow transplantation, in cancer patients suffering from the hematopoietic toxicity associated with chemotherapy and radiation therapy, and in patients with acquired immunodeficiency syndrome (AIDS).

译文

粒细胞巨噬细胞集落刺激因子 (gm-csf) 是调节造血的四大集落刺激因子 (CSF) 之一。Gm-csf可以刺激单个骨髓干细胞增殖并分化为成熟的中性粒细胞,嗜酸性粒细胞,粒细胞或巨噬细胞。最近的临床试验结果表明,gm-csf有望在临床上有效地增强自体骨髓移植接受者,患有化学疗法和放射疗法相关造血毒性的癌症患者以及患者的造血功能恢复获得性免疫缺陷综合症 (AIDS)。

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