Glutamate is the principal excitatory neurotransmitter in the central nervous system, and is thought to be involved in the process of memory encoding and storage. Glutamate disturbances have also been reported in psychiatric disorders, such as schizophrenia and major depressive disorder (MDD), and in Alzheimer's disease. In this paper, we set out to study the relationship between cerebrospinal fluid (CSF) glutamate levels and memory performance, which we believe has not been reported previously. In particular, we focused on recall performance broken down by serial position. Our prediction was that the recency ratio (Rr), a novel cognitive marker of intellectual impairment, would be linked with CSF glutamate levels. We studied data from a group of cognitively intact elderly individuals, 28 of whom had MDD, while 19 were controls. Study results indicated that Rr levels, but no other memory score, were inversely correlated with CSF glutamate levels, although this was found only in individuals with late-life MDD. For comparison, glutamine or GABA were not correlated with any memory performance measure.

译文

谷氨酸是中枢神经系统中主要的兴奋性神经递质,被认为参与记忆的编码和存储过程。在精神疾病 (例如精神分裂症和重度抑郁症 (MDD)) 以及阿尔茨海默氏病中也有谷氨酸紊乱的报道。在本文中,我们着手研究脑脊液 (CSF) 谷氨酸水平与记忆性能之间的关系,我们认为以前没有报道过。特别是,我们专注于按序列位置细分的召回性能。我们的预测是,新近比 (Rr) 是一种新的智力障碍认知指标,将与CSF谷氨酸水平有关。我们研究了一组认知完整的老年人的数据,其中28例患有MDD,而19例为对照组。研究结果表明,Rr水平 (但没有其他记忆评分) 与CSF谷氨酸水平成反比,尽管这仅在晚期MDD患者中发现。为了进行比较,谷氨酰胺或GABA与任何记忆性能指标均不相关。

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