The objectives of this study was to evaluate and critically analyze all randomized clinical trials (RCTs) of ''alternative cancer cures'' (ACCs) for breast cancer. The electronic databases Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Allied and Complementary Medicine, Scirus, BIOSIS, CancerLit and CINAHL and for ongoing trials the MetaRegister at http://www.controlled-trials.com/ and the National Research Register at http://www.update-software.com/national/ were searched from their inception. Bibliographies of located studies were scanned. Unpublished or ongoing trials were identified through correspondence with experts in the field. Our own files were hand searched for further RCTs. Review methods included a systematic review of RCTs involving breast cancer patients treated with ACCs, survival, parameters indicative of tumor burden, disease progression, cancer recurrence, and cancer cure. Results were tabulated and summarized. Thirteen RCTs met the inclusion criteria. In most cases their methodological quality is low, with only two RCTs scoring ''4'' and four RCTs scoring ''3'' out of 5 possible points for methodological quality. The treatments tested included various methods of psychosocial support such as group support therapy, cognitive behavioral therapy cognitive existential group therapy, a combination of muscle relaxation training and guided imagery, the Chinese herbal remedy Shi Quan Da Bu Tang, thymus extract, transfer factor, melatonin, and factor AF2. Encouraging but not fully convincing results emerged for melatonin.

译文

这项研究的目的是评估和严格分析乳腺癌 “替代癌症疗法” (ACCs) 的所有随机临床试验 (rct)。电子数据库Cochrane对照试验,MEDLINE,EMBASE,联合和补充医学,Scirus,BIOSIS,CancerLit和CINAHL的中央注册,正在进行的试验的MetaRegister在http:// www.controlled-trials.com/和国家研究注册在http:// www.update-software.com/national/从一开始就被搜索过。扫描了定位研究的书目。通过与该领域专家的通信,确定了未发表或正在进行的试验。我们自己的文件被手工搜索以寻找更多的随机对照试验。审查方法包括对涉及接受ACCs治疗的乳腺癌患者的rct,生存率,指示肿瘤负担的参数,疾病进展,癌症复发和癌症治愈的系统审查。结果被制成表格并进行总结。13个rct符合纳入标准。在大多数情况下,它们的方法学质量较低,在方法学质量的5个可能点中,只有两个rct得分为 “4”,四个rct得分为 “3”。测试的治疗方法包括各种心理社会支持方法,例如团体支持疗法,认知行为疗法,认知存在的团体疗法,肌肉放松训练和指导图像的组合,中草药疗法石泉大补汤,胸腺提取物,转移因子,褪黑激素和因子af2。褪黑激素的结果令人鼓舞,但并不完全令人信服。

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