The coronavirus disease 2019 (COVID-19) pandemic caused by SARS coronavirus 2 (SARS-CoV-2) has caused significant morbidity and mortality for patients and stressed healthcare systems worldwide. The clinical features and outcomes of COVID-19 among immunosuppressed patients, who are at presumed risk for more severe disease but who may also have decreased detrimental inflammatory responses, are not well characterized. We review the existing literature on COVID-19 among immunocompromised populations ranging from cancer patients and solid organ transplant recipients to patients with HIV and those receiving immunomodulatory therapy for autoimmune disease. Patients with malignancy and solid organ transplant recipients may be at increased risk of severe COVID-19 disease and death whereas for those with other types of immunocompromise, current evidence is less clear. Overall, further prospective, controlled studies are needed to determine the attributable risk of immunocompromising conditions and therapies on COVID-19 disease prognosis.

译文

传染性非典型肺炎冠状病毒2 (传染性非典型肺炎-CoV-2) 引起的冠状病毒病2019 (新型冠状病毒肺炎) 大流行已导致全球患者和紧张的医疗保健系统的显着发病率和死亡率。在免疫抑制的患者中,COVID-19的临床特征和结果没有很好的特征,这些患者有可能患更严重的疾病的风险,但也可能有减少的有害炎症反应。我们回顾了免疫功能低下人群新型冠状病毒肺炎的现有文献,从癌症患者和实体器官移植受者到HIV患者以及接受自身免疫性疾病免疫调节疗法的患者。患有恶性肿瘤和实体器官移植受者的患者发生新型冠状病毒肺炎疾病和死亡的风险可能会增加,而对于患有其他类型免疫功能低下的患者,目前的证据尚不清楚。总体而言,需要进一步的前瞻性对照研究来确定免疫损害条件和治疗对新型冠状病毒肺炎疾病预后的归因风险。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录