The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a longitudinal multisite observational study of healthy elders, mild cognitive impairment (MCI), and Alzheimer's disease. Magnetic resonance imaging (MRI), (18F)-fluorodeoxyglucose positron emission tomography (FDG PET), urine serum, and cerebrospinal fluid (CSF) biomarkers, as well as clinical/psychometric assessments are acquired at multiple time points. All data will be cross-linked and made available to the general scientific community. The purpose of this report is to describe the MRI methods employed in ADNI. The ADNI MRI core established specifications that guided protocol development. A major effort was devoted to evaluating 3D T(1)-weighted sequences for morphometric analyses. Several options for this sequence were optimized for the relevant manufacturer platforms and then compared in a reduced-scale clinical trial. The protocol selected for the ADNI study includes: back-to-back 3D magnetization prepared rapid gradient echo (MP-RAGE) scans; B(1)-calibration scans when applicable; and an axial proton density-T(2) dual contrast (i.e., echo) fast spin echo/turbo spin echo (FSE/TSE) for pathology detection. ADNI MRI methods seek to maximize scientific utility while minimizing the burden placed on participants. The approach taken in ADNI to standardization across sites and platforms of the MRI protocol, postacquisition corrections, and phantom-based monitoring of all scanners could be used as a model for other multisite trials.

译文

阿尔茨海默氏病神经影像学倡议 (ADNI) 是一项针对健康老年人,轻度认知障碍 (MCI) 和阿尔茨海默氏病的纵向多站点观察研究。在多个时间点获得磁共振成像 (MRI),(18F)-氟脱氧葡萄糖正电子发射断层扫描 (FDG PET),尿液血清和脑脊液 (CSF) 生物标志物以及临床/心理评估。所有数据都将相互链接,并提供给一般科学界。本报告的目的是描述ADNI中使用的MRI方法。ADNI MRI核心建立了指导协议开发的规范。致力于评估3D T(1) 加权序列以进行形态计量分析。针对该序列的几种选择已针对相关制造商平台进行了优化,然后在缩减规模的临床试验中进行了比较。为ADNI研究选择的协议包括: 背靠背3D磁化准备的快速梯度回波 (MP-RAGE) 扫描; B(1)-适用时的校准扫描; 和轴向质子密度-T(2) 双重对比度 (即,echo) 快速自旋回波/turbo自旋回波 (FSE/TSE) 用于病理检测。ADNI MRI方法寻求最大程度地提高科学效用,同时最大程度地减少参与者的负担。ADNI采取的跨MRI协议的站点和平台标准化,采集后校正和所有扫描仪的基于幻影的监视的方法可以用作其他多站点试验的模型。

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