PURPOSE:The value of high resolution computed tomography (HR-CT) in the recognition of pathologic changes of the lung parenchyma, especially in the diagnosis of sarcoidosis, is well established. The importance of these findings in regard to the inflammatory activity is not sufficiently documented, also because a direct histologic correlation is seldom possible.

METHOD:In a prospective study twenty-one patients with suspected or known sarcoidosis were evaluated. The diagnostic work up comprised the clinical examination, lung function tests, the radiological evaluation, including GH-CT, and bronchoscopy for bronchoalveolar lavage (BAL) and transbronchial biopsy.

RESULTS:The comparison of the HR-CT findings, like pathologic appearance of the bronchovascular bundle and intraparenchymal nodules, with serologic and BAL-parameters yielded high correlation coefficients with the total cell count in BAL and sIL-2R, and moderate correlations with the lavage lymphocyte count and the activity markers, like T4/T8 ratio, IL-2R and HLA-DR expression.

CONCLUSION:As a non invasive method, HR-CT depicts pathologic findings of the lung parenchyma which are associated with the inflammatory activity of sarcoidosis.

译文

目的 : 高分辨率计算机断层扫描 (hr-ct) 在识别肺实质的病理变化,特别是在结节病的诊断中的价值已得到充分确立。这些发现在炎症活性方面的重要性尚未得到充分证明,这也是因为很少有直接的组织学相关性。
方法 : 在一项前瞻性研究中,对21例疑似或已知结节病患者进行了评估。诊断工作包括临床检查,肺功能检查,放射学评估 (包括gh-ct) 以及支气管镜检查 (用于支气管肺泡灌洗 (BAL) 和经支气管活检)。
结果 : hr-ct结果的比较,像支气管血管束和实质内结节的病理外观一样,血清学和BAL参数与BAL和sIL-2R的总细胞计数具有高相关系数,与灌洗淋巴细胞计数和活性标志物 (如T4/T8比率) 具有中等相关性,IL-2R和hla-dr表达。
结论 : 作为一种非侵入性方法,hr-ct描述了与结节病的炎症活性相关的肺实质的病理发现。

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