To investigate the correlation between the proliferating cell nuclear antigen Ki-67 and the multislice computed tomography (MSCT) signs in different subtypes of lung adenocarcinoma.Ninety-five patients with lung adenocarcinoma confirmed by surgical pathology and treated between January 2017 and December 2017 were included. MSCT was performed before the operation, and the characteristics of the high-resolution CT (HRCT) signs of the lesions were compared with the Ki-67 immunohistochemistry results.The levels of Ki-67 in the 95 lung adenocarcinoma specimens were positively correlated with the malignancy of lung adenocarcinoma. Spearman correlation coefficient was 0.615. The expression of Ki-67 was positively correlated with the nodules' diameter, density, and lobulated sign, with Spearman correlation coefficients of 0.58, 0.554, and 0.436. There was no significant correlation with spiculation and pleural retraction, with correlation coefficients of 0.319/0.381.These findings suggest that the MSCT signs of different types of lung adenocarcinoma might be associated with the expression of Ki-67. Without replacing biopsy, the imaging features of pulmonary nodules could be comprehensively analyzed to evaluate the proliferation potential of preoperative nodules, but additional studies are needed for confirmation.

译文

探讨不同亚型肺腺癌中增殖细胞核抗原Ki-67与多层螺旋ct (MSCT) 征象的相关性。包括95例经手术病理证实并经2017年1月和2017年12月治疗的肺腺癌患者。术前行MSCT检查,并将病灶的高分辨率CT (HRCT) 征象特征与Ki-67免疫组织化学结果进行比较,发现95例肺腺癌标本的Ki-67水平与肺腺癌的恶性程度呈正相关。Spearman相关系数为0.615。Ki-67的表达与结节的直径,密度和分叶征呈正相关,Spearman相关系数为0.58,0.554和0.436。与毛刺、胸膜回缩无明显相关性,相关系数为0.319/0.381,提示不同类型肺腺癌的MSCT征象可能与Ki-67的表达有关。在不更换活检的情况下,可以全面分析肺结节的影像学特征,以评估术前结节的增殖潜力,但还需要进一步的研究来证实。

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