A significant dose-response relation between ingested arsenic and several cancers has recently been reported in four townships of the endemic area of blackfoot disease, a unique peripheral artery disease related to the chronic arsenic exposure in southwestern Taiwan. This study was carried out to examine ecological correlations between arsenic level of well water and mortality from various malignant neoplasms in 314 precincts and townships of Taiwan. The arsenic content in water of 83,656 wells was determined by a standard mercuric bromide stain method from 1974 to 1976, while mortality rates of 21 malignant neoplasms among residents in study precincts and townships from 1972 to 1983 were standardized to the world population in 1976. A significant association with the arsenic level in well water was observed for cancers of the liver, nasal cavity, lung, skin, bladder and kidney in both males and females as well as for the prostate cancer in males. These associations remained significant after adjusting for indices of urbanization and industrialization through multiple regression analyses. The multivariate-adjusted regression coefficient indicating an increase in age-adjusted mortality per 100,000 person-years for every 0.1 ppm increase in arsenic level of well water was 6.8 and 2.0, 0.7 and 0.4, 5.3 and 5.3, 0.9 and 1.0, 3.9 and 4.2, as well as 1.1 and 1.7, respectively, in males and females for cancers of the liver, nasal cavity, lung, skin, bladder and kidney. The multivariate-adjusted regression coefficient for the prostate cancer was 0.5. These weighted regression coefficients were found to increase or remain unchanged in further analyses in which only 170 southwestern townships were included.

译文

最近在黑脚病流行区的四个乡镇报道了摄入砷与几种癌症之间的显着剂量反应关系,黑脚病是与台湾西南部慢性砷暴露有关的独特外周动脉疾病。进行这项研究是为了研究台湾314地区和乡镇井水砷水平与各种恶性肿瘤死亡率之间的生态相关性。1974年1976年,通过标准的溴化汞染色方法确定了83,656口井中的砷含量,而研究区和1983年1972年乡镇居民中21例恶性肿瘤的死亡率则按照世界人口1976年进行了标准化。在男性和女性的肝脏,鼻腔,肺,皮肤,膀胱和肾癌以及男性的前列腺癌中,观察到与井水中的砷含量显着相关。通过多元回归分析对城市化和工业化指数进行调整后,这些关联仍然很重要。表明井水砷水平每增加0.1 ppm,每100,000人年年龄调整死亡率增加的多变量调整回归系数分别为6.8和2.0、0.7和0.4、5.3和5.3、0.9和1.0、3.9和4.2,以及1.1和1.7,在男性和女性的肝癌,鼻腔,肺癌,皮肤,膀胱癌和肾癌。0.5前列腺癌的多变量调整回归系数。在仅包括170个西南乡镇的进一步分析中,发现这些加权回归系数增加或保持不变。

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