This study was designed to validate the utility of a commercial portable clinical blood analyzer (PCBA) in ground-based studies and on the space shuttle. Ionized calcium, pH, electrolytes, glucose, and hematocrit were determined. Results agreed well with those from traditional laboratory methods, and the PCBA demonstrated good between-day precision for all analytes. In-flight analysis of control samples revealed differences in one analyte (sodium). There were few changes in crew members' results during flight, and these were expected. Potassium increased in flight compared with before flight, and potassium, pH, and hematocrit decreased after flight. Ionized calcium was decreased in flight and on landing day. Changes during flight were likely related to sample collection technique. Postflight changes likely reflected the fluid redistribution that occurs after exposure to weightlessness. These data confirm that the PCBA is a reliable instrument for most analytes, and can provide important medical data in remote locations, such as orbiting spacecraft.

译文

这项研究旨在验证商用便携式临床血液分析仪 (PCBA) 在地面研究和航天飞机上的实用性。测定了离子钙,pH,电解质,葡萄糖和血细胞比容。结果与传统实验室方法的结果非常吻合,并且PCBA对所有分析物均显示出良好的日间精度。对照样品的飞行分析显示一种分析物 (钠) 存在差异。在飞行过程中,机组人员的结果几乎没有变化,这是可以预料的。与飞行前相比,飞行中钾增加,飞行后钾,pH和血细胞比容降低。在飞行中和着陆日,离子钙减少。飞行过程中的变化可能与样品收集技术有关。飞行后的变化可能反映了失重后发生的流体重新分布。这些数据证实了PCBA对于大多数分析物来说是一种可靠的仪器,并且可以在偏远的地方提供重要的医学数据,例如绕行航天器。

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