The occurrence of upper gastrointestinal disease and the relevance of nonsteroidal antiinflammatory drug (NSAID) usage were documented in 511 consecutive patients (321 women, 190 men) over 70 yr old, referred for upper gastrointestinal endoscopy in a district general hospital. The findings were benign esophageal disease (43%), normal (15%), gastric ulcer (11.5%), and duodenal ulcer (11%). Gastric ulcers were more common in women taking NSAIDs (25%) than in NSAID abstainers (7%) p less than 0.001 and male NSAID users (8%) p less than 0.001. Esophagitis and esophageal stricture were not influenced by NSAID usage, but gastric erosions were more common (10% vs. 3%) p less than 0.01. Of 142 patients receiving NSAIDs, 41% presented with hemorrhage, compared with 20.5% of NSAID abstainers (p less than 0.001). Hemorrhage was as common in aspirin takers (15 of 33, 45%) as in standard-dose NANSAID takers (43 of 109, 39%), even though 86% were taking 300 mg of aspirin per day or less. In elderly patients, esophageal disease is common. NSAID use, even low-dose aspirin, is associated with an increased risk of hemorrhage. In females, NSAID usage is associated with gastric ulcer.

译文

在地区综合医院接受上消化道内窥镜检查的连续511例患者 (321例女性,190例男性) 中记录了上消化道疾病的发生和非甾体抗炎药 (NSAID) 使用的相关性。结果为良性食管疾病 (43%),正常 (15%),胃溃疡 (11.5%) 和十二指肠溃疡 (11%)。服用NSAID (25%) 的女性比NSAID戒除者 (7%) p小于0.001和男性NSAID使用者 (8%) p小于0.001的女性更常见胃溃疡。食管炎和食管狭窄不受NSAID使用的影响,但胃糜烂更常见 (10% 比3%) p小于0.01。在接受NSAID的142例患者中,41% 例出现出血,而NSAID戒除者的20.5% 例 (p小于0.001)。即使86% 每天服用300毫克或更少的阿司匹林,出血在阿司匹林接受者 (33人中的15人,45%) 与标准剂量NANSAID接受者 (109人中的43人,39% 人) 中一样常见。在老年患者中,食道疾病很常见。使用NSAID,即使是低剂量的阿司匹林,也会增加出血的风险。在女性中,使用NSAID与胃溃疡有关。

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