We examined the effect of menstrual cycle (MC) phase on acid-base regulation and ventilatory control at rest in monophasic oral contraceptive (OC) users. Twelve healthy women (25+/-1 years; mean+/-S.E.) were tested during the inactive (IP; 5.1+/-0.2 days) and active (AP; 21.1+/-0.7 days) pill phase of the MC. Central and peripheral chemoreflex responsiveness was examined using a modified CO(2) rebreathing procedure. Minute ventilation (V E), breathing pattern and metabolic rate were measured during 10 min of quiet, resting breathing. Blood for the determination of arterial P(CO2) (Pa(CO2)) and hydrogen ion concentration ([H(+)]); plasma concentrations of the strong ion difference ([SID]) and total weak acid ([A(tot)]); serum concentrations of progesterone ([P(4)]) and 17beta-estradiol ([E(2)]) were also obtained. Although [E(2)] (p<0.05) and [A(tot)] (p=0.05) were increased in the IP versus AP, MC phase had no significant effect on resting V E, breathing pattern, metabolic rate, [H(+)], Pa(CO2), [SID], [P(4)] and central or peripheral chemoreflex characteristics. Overall, OC had no significant physiological effect on acid-base regulation or ventilatory control at rest in healthy women. This may reflect suppression of endogenous fluctuations in circulating [P(4)] typically observed across the MC in healthy, eumenorrheic non-OC users.

译文

我们检查了单相口服避孕药 (OC) 使用者的月经周期 (MC) 阶段对静息时酸碱调节和通气控制的影响。在MC的非活性 (IP; 5.1 +/-0.2天) 和活性 (AP; 21.1 +/-0.7天) 药丸期测试了12名健康女性 (25 +/-1岁; 平均 +/-S.E.)。使用改良的CO(2) 再呼吸程序检查了中枢和外周化学反射的反应性。在安静的静息呼吸10分钟内,测量分钟通气 (V E),呼吸方式和代谢率。血液测定动脉P(CO2) (Pa(CO2)) 和氢离子浓度 ([H(+)]); 血浆浓度的强离子差 ([SID]) 和总弱酸 ([A(tot)]); 还获得了孕酮 ([P(4)]) 和17β-雌二醇 ([E(2)]) 的血清浓度。尽管与AP相比,IP中 [E(2)] (p<0.05) 和 [A(tot)] (p = 0.05) 增加,但MC期对静息V E,呼吸方式,代谢率,[H(+)],pa (CO2),[SID],[P(4)] 和中央或外围化学反射特性。总体而言,OC对健康女性休息时的酸碱调节或通气控制没有显着的生理作用。这可能反映了在健康的,正常的非OC用户中,通常在MC中观察到的循环 [P(4)] 内源性波动的抑制。

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