In this study, we investigated the yeasts colonization of genus Candida, including C. dubliniensis, isolated of HIV-infected patients oral cavities and we accessed in vitro susceptibility pattern of the Candida isolates to four antifungal agents. Out of 99 patients investigated, 62 (62.6%) were colonized with yeasts. C. albicans was the prevailing species (50%). C. dubliniensis isolates were not recovered in our study. We verified that 8.1% of the yeasts isolated were resistant to fluconazole, 8.1% to itraconazole and 3.2% to voriconazole. The isolates demonstrated very low voriconazole MICs, in which 79% (49/62) presented values of 0.015 mug/ml. All Candida isolates were susceptible to amphotericin B. The results reported here showed that although C. albicans continues to be present in one-half of oral Candida carriage of HIV-infected patients, Candida non-albicans species are increasing among these patients. Besides, the findings of resistant isolates endorse the role of antifungal susceptibility testing whenever antifungal treatment with azoles is planned.

译文

在这项研究中,我们调查了念珠菌属 (包括杜氏杆菌) 的酵母菌定植,这些酵母菌是HIV感染患者口腔的分离物,并研究了念珠菌分离株对四种抗真菌剂的体外敏感性模式。在调查的99例患者中,有62例 (62.6% 例) 被酵母定植。白色念珠菌是主要物种 (50%)。在我们的研究中没有回收杜氏杆菌分离株。我们证实了8.1% 分离出的酵母对氟康唑,8.1% 对伊曲康唑和3.2% 对伏立康唑具有抗性。分离物显示出非常低的伏立康唑mic,其中79% (49/62) 呈现0.015 mug/ml的值。所有念珠菌分离株均对两性霉素b敏感。此处报道的结果表明,尽管白色念珠菌继续存在于HIV感染患者的口腔念珠菌的一半中,但这些患者中的非白色念珠菌种类正在增加。此外,每当计划用唑类药物进行抗真菌治疗时,耐药分离株的发现都认可了抗真菌药敏试验的作用。

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