Fine mapping of calcineurin (PPP3CA) gene identified single nucleotide polymorphisms (SNPs) and simple sequence repeat polymorphisms that are associated with addiction vulnerability. A trinucleotide repeat marker, located in the 5'untranslated region (5'UTR) of the PPP3CA mRNA, exhibited significantly different genotype and allele frequencies between abusers and controls in the NIDA African-American sample. The polymorphism showed allelic-specific expression in mRNA extracted from postmortem brain specimens. Novel alternatively spliced isoforms of PPP3CA were identified and their expressions were found altered in brain regions of postmortem Alzheimer's disease patients. These data underscore the importance of calcineurin gene in the molecular mechanism of addiction and Alzheimer's diseases.

译文

钙调神经磷酸酶 (PPP3CA) 基因的精细定位确定了与成瘾脆弱性相关的单核苷酸多态性 (snp) 和简单序列重复多态性。位于PPP3CA mRNA的5' 非翻译区 (5'UTR) 的三核苷酸重复标记在NIDA非裔美国人样品中的滥用者和对照之间表现出显着不同的基因型和等位基因频率。多态性显示从死后脑标本中提取的mRNA中的等位基因特异性表达。鉴定出PPP3CA的新型剪接同工型,并在死后阿尔茨海默氏病患者的大脑区域发现它们的表达发生了变化。这些数据强调了钙调神经磷酸酶基因在成瘾和阿尔茨海默氏病分子机制中的重要性。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录