Sex hormone replacement therapy provides several advantages in the quality of life for climacteric women. However, estrogen-induced cell proliferation in the uterus and mammary gland increases the risk of cancer development in these organs. The lower incidence of mammary cancer in Asian women as compared with Western women has been attributed to high intake of soy isoflavones, including genistein. We have previously shown that genistein induces an estradiol-like hypertrophy of uterine cells, but does not induce cell proliferation, uterine eosinophilia, or endometrial edema. It also inhibits estradiol-induced mitosis in uterine cells and hormone-induced uterine eosinophilia and endometrial edema. Nevertheless, genistein stimulates growth of human breast cancer cells in culture; therefore, it is not an ideal estrogen for use in hormone replacement therapy (HRD). The present study investigated the effect of another soy isoflavone, daidzein (subcutaneous, 0.066 mg/kg body weight), in the same animal model, and its effect on responses induced by subsequent treatment (1 h later) with estradiol-17β (E(2); subcutaneous, 0.33 mg/kg body weight). In addition, we investigated the effects of daidzein (1 μg/mL) or E(2) on the growth of human breast cancer cells in culture. Results indicate that daidzein stimulates growth of breast cancer cells and potentiates estrogen-induced cell proliferation in the uterus. We suggest caution for the use of daidzein or formulas containing this compound in HRD. Future research strategies should be addressed in the search for new phytoestrogens that selectively inhibit cell proliferation in the uterus and breast.

译文

性激素替代疗法为更年期妇女的生活质量提供了一些优势。然而,雌激素诱导的子宫和乳腺细胞增殖增加了这些器官发生癌症的风险。与西方女性相比,亚洲女性的乳腺癌发病率较低,这归因于大豆异黄酮 (包括染料木黄酮) 的大量摄入。我们以前已经证明,金雀异黄素可诱导子宫细胞的雌二醇样肥大,但不会诱导细胞增殖,子宫嗜酸性粒细胞增多或子宫内膜水肿。它还抑制雌二醇诱导的子宫细胞有丝分裂和激素诱导的子宫嗜酸性粒细胞增多和子宫内膜水肿。然而,金雀异黄素刺激培养物中人类乳腺癌细胞的生长; 因此,它不是用于激素替代疗法 (HRD) 的理想雌激素。本研究调查了另一种大豆异黄酮大豆苷元 (皮下,0.066 mg/kg体重) 在同一动物模型中的作用,及其对随后用雌二醇-17β (E(2) 治疗 (1小时后) 诱导的反应的影响; 皮下,0.33 mg/kg体重)。此外,我们研究了大豆苷元 (1 μ g/mL) 或E(2) 对培养物中人乳腺癌细胞生长的影响。结果表明,大豆苷元刺激乳腺癌细胞的生长并增强雌激素诱导的子宫细胞增殖。我们建议在HRD中使用大豆苷元或含有该化合物的配方谨慎。在寻找选择性抑制子宫和乳房细胞增殖的新型植物雌激素时,应考虑未来的研究策略。

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