Ovarian primary carcinoid tumors of pure histological type can pose a significant diagnostic challenge in its separation from metastatic carcinoids from the gastrointestinal tract. Yet, their clinical management and prognosis are drastically different. At the molecular level, ovarian primary carcinoid tumors are thought to be of germ cell origin, frequently after the first meiotic division. We report a 21.5-cm ovarian insular carcinoid tumor in a 50-year-old woman who had no evidence of extraovarian tumor. The absence of teratomatous components and the presence of lymphovascular invasion prompted additional studies to rule out a metastatic tumor. The nature of this primary ovarian tumor was eventually confirmed by demonstration of its germ cell origin through DNA genotyping.

译文

纯组织学类型的卵巢原发性类癌在从胃肠道与转移性类癌的分离中可能构成重大的诊断挑战。然而,他们的临床管理和预后截然不同。在分子水平上,卵巢原发性类癌被认为是生殖细胞起源的,通常是在第一次减数分裂之后。我们报告了一名50岁女性的21.5厘米卵巢岛状类癌,该女性没有卵巢外肿瘤的证据。畸胎瘤成分的缺乏和淋巴血管浸润的存在促使其他研究排除了转移性肿瘤。通过DNA基因分型证明其生殖细胞起源,最终证实了这种原发性卵巢肿瘤的性质。

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